Research status of src-homology 2 domain-containing protein tyrosine phosphatase 1 in liver diseases / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 1128-1133, 2017.
Artigo
em Chinês
| WPRIM
| ID: wpr-838478
ABSTRACT
Protein tyrosine phosphorylation is ubiquitously found in eukaryotic cells, and it is a fundamental regulatory mechanism to be involved in the regulation of cell proliferation, apoptosis, differentiation and migration. Dysregulation of protein tyrosine phosphorylation can influence various liver diseases, such as liver inflammation, liver fibrosis and liver cancer. The src-homology 2 domain-containing protein tyrosine phosphatase 1 (SHP-1), a nonreceptor type protein tyrosine phosphatase, is a key regulator of maintaining protein tyrosine phosphorylation level in vivo. Recently, great progress in the research of SHP-1 in liver diseases has been made, and this review summed up the advances of SHP-1 in liver diseases.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Academic Journal of Second Military Medical University
Ano de publicação:
2017
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS