Endoplasmic Reticulum Stress and the Related Signaling Networks in Severe Asthma
Allergy, Asthma & Immunology Research
;
: 106-117, 2015.
Artigo
em Inglês
| WPRIM
| ID: wpr-83887
ABSTRACT
The endoplasmic reticulum (ER) is a specialized organelle that plays a central role in biosynthesis, correct protein folding, and posttranslational modifications of secretory and membrane proteins. Loss of homeostasis in ER functions triggers the ER stress response, resulting in activation of unfolded protein response (UPR), a hallmark of many inflammatory diseases. These pathways have been reported as critical players in the pathogenesis of various pulmonary disorders, including pulmonary fibrosis, lung injury, and chronic airway disorders. More interestingly, ER stress and the related signaling networks are emerging as important modulators of inflammatory and immune responses in the development of allergen-induced bronchial asthma, especially severe asthma.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Fibrose Pulmonar
/
Asma
/
Organelas
/
Processamento de Proteína Pós-Traducional
/
Dobramento de Proteína
/
Retículo Endoplasmático
/
Lesão Pulmonar
/
Resposta a Proteínas não Dobradas
/
Estresse do Retículo Endoplasmático
/
Homeostase
Idioma:
Inglês
Revista:
Allergy, Asthma & Immunology Research
Ano de publicação:
2015
Tipo de documento:
Artigo
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