Detection and clinical significance of regulatory T cells in peripheral blood of elderly patients with type 2 diabetic peripheral neuropathy / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 1007-1011, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-839007
ABSTRACT
Objective To investigate the changes of CD4+CD25+Foxp3+ regulatory T cell (Treg) in the peripheral blood of elderly patients with type 2 diabetic peripheral neuropathy (DPN) and its clinical implication. Methods Treg cells were detected by flow cytometry in the peripheral blood of elderly patients with type 2 DPN (DNP group, 20 cases), type 2 diabetes mellitus (T2DM) with no complications (T2DM group, 20 cases) and age-matched healthy volunteers (CON group, 20 cases). The results were statistically analyzed and compared between different groups. Results The numbers of CD4+CD25+Foxp3+ Treg in DPN group and T2DM group were significantly less than that in the healthy volunteers (P<0.05), and the number of Treg cells in DPN group was significantly less than that in T2DM group (P<0.05). The proportion of CD4+CD25+Foxp3+ Treg was negatively associated with Michigan neuropathy screening instrument (MNSI) scores in DPN group, but with no statistical significance; however, the proportion had a significantly negative correlation with Michigan diabetic neuropathy score (r=-0.339, P<0.05). Conclusion The number of CD4+CD25+Foxp3+ Treg is decreased in the peripheral blood of elderly patients with DPN, which may play a role in the development and progression of DPN in elderly patients.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo diagnóstico
Idioma:
Chinês
Revista:
Academic Journal of Second Military Medical University
Ano de publicação:
2015
Tipo de documento:
Artigo
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