A new 3, 4-epoxyfurocoumarin from Heracleum moellendorffii Roots
Natural Product Sciences
;
: 213-216, 2017.
Artigo
em Inglês
| WPRIM
| ID: wpr-83903
ABSTRACT
Activity-guided isolation of Heracleum moellendorffii roots led to four coumarin derivatives as acetylcholinesterase inhibitors. The structures of these isolates were characterized by spectroscopic method to be angelicin (1), isobergapten (2), pimpinellin (3), and (3S, 4R)-3, 4-epoxypimpinellin (4). All the isolated compounds 1, 2, 3, and 4 showed moderate inhibition activities against acetylcholinesterase with the IC₅₀ values of 10.2, 18.1, 21.5 and 22.9 µM, respectively. (3S, 4R)-3, 4-Epoxypimpinellin (4) was newly isolated from the plant source.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Plantas
/
Acetilcolinesterase
/
Inibidores da Colinesterase
/
Cumarínicos
/
Heracleum
/
Métodos
Idioma:
Inglês
Revista:
Natural Product Sciences
Ano de publicação:
2017
Tipo de documento:
Artigo
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