Lack of dopamine D2 receptor exacerbates MPTP-induced Parkinson's disease in mice / 第二军医大学学报

ABSTRACT

Results After MPTP injection, the animals had a significantly longer time in pole testing, a significantly decreased score in swimming test, and a significantly decreased number of TH-positive neurons in the substantia nigra of the midbrain (P < 0. 05 or P<0. 01). Moreover, the behavioral changes and the decrease of TH-positive neuron numbers in D2-/- mice were more significant than those in the WT mice(P< 0. 05 or P<0. 01).