Nitration of α-Synuclein in Parkinson disease: Recent progress / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 423-428, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-839291
ABSTRACT
Parkinson disease (PD) is characterized by the degeneration of dopaminergic neurons in the substantial nigra and the formation of intracellular Lewy body. Protein nitration due to oxidative and nitrative stress has been linked to the pathogenesis of PD. Here we described the biophysical and biochemical properties of α-synuclein and nitrated α-synuclein protein and reviewed their biological consequences; finally we discussed their roles in the mechanism and prevention/treatment of PD.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Academic Journal of Second Military Medical University
Ano de publicação:
2014
Tipo de documento:
Artigo
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