A Case of Prader-Willi Syndrome with Microdeletion of Chromosome 15 q11-q13 Confirmed by FISH / 대한소아내분비학회지
Journal of Korean Society of Pediatric Endocrinology
; : 145-152, 1997.
Article
em Ko
| WPRIM
| ID: wpr-83954
Biblioteca responsável:
WPRO
ABSTRACT
Prader-Willi(PW)syndrome is characterized by obesity, hypotonia, mental retardation, hypogonadism, short stature, excessive eating and characteristic facial appearance. Diabetes mellitus has been considered a component of PW syndrome. Recently this syndrome is caused by the absence of paternally derived genes normally located on chromosome segment 15 q11-q13 or may be the result of maternal uniparental disomy with the absence of paternally derived 15 q11-q13 region. The developement of probes containing segments of DNA from chromosome region 15 q11-q13 provides the oppotunity to confirm the diagnosis of PW syndrome by fluorescence in situ hybridization(FISH). We experienced a 15-year-old boy of PW syndrome with diabetes mellitus, who revealed mental retardation, hypogonadism, obesity and microdeletion of chromosome 15 q11-q13 comfirmed by FISH.
Palavras-chave
Texto completo:
1
Índice:
WPRIM
Assunto principal:
Síndrome de Prader-Willi
/
Cromossomos Humanos Par 15
/
DNA
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Dissomia Uniparental
/
Diabetes Mellitus
/
Diagnóstico
/
Ingestão de Alimentos
/
Fluorescência
/
Hipogonadismo
/
Deficiência Intelectual
Tipo de estudo:
Diagnostic_studies
Limite:
Adolescent
/
Humans
/
Male
Idioma:
Ko
Revista:
Journal of Korean Society of Pediatric Endocrinology
Ano de publicação:
1997
Tipo de documento:
Article