Anti-LGI1 Limbic Encephalitis Presented with Atypical Manifestations
Experimental Neurobiology
;
: 337-340, 2013.
Artigo
em Inglês
| WPRIM
| ID: wpr-84001
ABSTRACT
Anti-leucine-rich glioma inactivated-1 (LGI1) limbic encephalitis (LE) is a rare neurological disorder that has a subacute course of progressive encephalopathy and fasciobrachial dystonic seizures. We report a patient with anti-LGI1 LE that presented with atypical manifestations that complicated the diagnosis. A 62-year-old woman presented with a chronic course of memory disturbance and a subsequent relapse with an altered mental status after 10 months. The patient reported frequent chest pain of squeezing and dull nature, typically lasting 10-30 seconds. The chest pain was related to partial seizures, which were confirmed by video-EEG monitoring. Anti-LGI1 antibody was identified in serum and CSF. The patient's symptoms improved by immune modulation treatment. Patients with anti-LGI1 LE can experience atypical partial seizures, and a chronic relapsing course. Clinical suspicions and video-EEG monitoring are helpful for the early diagnosis and effective immune modulation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Assunto principal:
Recidiva
/
Convulsões
/
Dor no Peito
/
Encefalite Límbica
/
Diagnóstico Precoce
/
Diagnóstico
/
Glioma
/
Memória
/
Doenças do Sistema Nervoso
Tipo de estudo:
Estudo diagnóstico
/
Estudo de rastreamento
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
Experimental Neurobiology
Ano de publicação:
2013
Tipo de documento:
Artigo
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