Long non-coding RNA: Research progress / 第二军医大学学报

ABSTRACT

Long non-coding RNA (lncRNA) is a functional RNA segment longer than 200 nucleotides, with little or no protein-coding capacity. LncRNAs can regulate gene expression at epigenetic, transcription and post-transcription level, and widely participate in various physiological and pathological processes. More than one thousand lncRNAs have been found participating in the gene regulation of mammals. However, the functions and mechanism of lncRNA and its relation with disease remain poorly understood. This paper reviews the progress in lncRNA function study and the role of lncRNA in the development and progression of clinical disease.