Expression of atrial angiotensin II type 1 receptor and α7-nicotinic acetylcholine receptor during development of heart failure in rats / 第二军医大学学报

ABSTRACT

Objective: To observe the atrial expression of angiotensin II receptor type 1 (AT1R) and α7-nicotinic acetylcholine receptor(α7nAChR) during the development of heart failure in rats. Methods: Male SD rats were randomly divided into 4 groups. Abdominal aorta coarctation (AAC) was used to prepare heart failure model. Expression of AT1R and α7nAChR was determined by Western blotting analysis at 4,8,12, and 16 weeks after AAC in all the groups. Results: Compared with the control group, expression of AT1R and α7nAChR in AAC group was not significantly different at all the 4 time points after AAC. Conclusion: Our findings suggest that atrial AT1R and α7nAChR may not be involved in the early stage pathological process of AAC-induced heart failure.