Three programmed systems for pulsed drug delivery / 第二军医大学学报
Academic Journal of Second Military Medical University
; (12): 782-786, 2010.
Article
em Zh
| WPRIM
| ID: wpr-840273
Biblioteca responsável:
WPRO
ABSTRACT
Pulsed drug delivery (PDD), which can be released at well-defined time points as the therapy needs, can decrease the frequency and avoid taking drug at night, thus improving patient compliance. Here we introduce three kinds of programmed PDD systems independent of external chemical triggering; they are divided according to the triggering mechanisms, degradation-triggered PDD, osmotic pressure-triggered PDD, and both degradationi and osmotic pressure-triggered PDD. This paper reviews preparing technique, release mechanisms and influencing factors of the three PDD systems. The release profiles of pulsatile PDD can be regulated for different therapeutic needs, requiring no external triggers; especially that the PDD system triggered by both degradation and osmotic pressure has a bright future.
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Índice:
WPRIM
Idioma:
Zh
Revista:
Academic Journal of Second Military Medical University
Ano de publicação:
2010
Tipo de documento:
Article