Role of protease activated receptor-2 in rheumatoid arthritis: Recent progress / 第二军医大学学报

ABSTRACT

Protease activated receptor-2 (PAR-2) is a G-protein-coupled receptor. Recent studies indicate that PAR-2 is mainly expressed in leukocytes and activated by pancreatin and (or) tryptase, which subsequently induces inflammation through degranulation of leukocytes. Activation of PAR-2 in leukocytes is possibly involved in the pathogenesis of rheumatoid arthritis.