Changes of PTEN gene expression in radiation-induced bystander cells / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 137-141, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-840647
ABSTRACT
Objective:
To study the changes of PTEN gene expression in radiation-induced bystander cells.Methods:
The irradiated cells and non-irradiated cells were co-cultured in a ratio of 11. The culture medium of irradiated cells was used to culture non-irradiated cells to create two bystander cell models. The expression of PTEN mRNA and protein in the bystander cells, irradiated cells, non-irradiated cells was compared.Results:
The protein expression of PTEN in the irradiated cells was negatively associated with the irradiation dose. The down-regulation degree of PTEN protein was related to the different treatments of cells. The most prominent down-regulation was found in the bystander cells cultured with medium of irradiated cells. The down-regulation of PTEN protein in the two kinds of bystander cells was more severe than that in the irradiated cells (P<0.01).Conclusion:
PTEN protein expression can be influenced by low dose radiation and the bystander effect of radiation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Academic Journal of Second Military Medical University
Ano de publicação:
2010
Tipo de documento:
Artigo
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