Expression of MMP-9 in brain tissue of mouse cryptococcal meningitis model / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 778-780, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-840816
ABSTRACT
Objective:
To explore the expression of MMP-9 in mouse brain tissue and its significance.Methods:
Cryptococcosis ssuspension alone (fungal suspension group) or combined with aprotinin (aprotinin group) was injected in to female C57 BL/6 mice via femoral vein cannulation. The expression of MMP-9 was examined immunohistochemically 8 h later. Meanwhile, the mouse brain tissue homogenate colony count (CFU) was observed and the results were compared with that of the immunohistochemical examination.Results:
The expression of MMP-9 was markedly increased in the fungal suspension group compared with the normal control group (P0.05). The amount of cryptococcosis in the brain tissue was positively correlated with expression of MMP-9.Conclusion:
MMP-9 is overexpressed in the brain of mice with Cryptococcal meningitis; MMP-9 might lead to increased permeability of blood brain barrier.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Academic Journal of Second Military Medical University
Ano de publicação:
2010
Tipo de documento:
Artigo
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