The association between breast carcinoma and columnar alteration with prominent apical snouts and secretions / 第二军医大学学报

ABSTRACT

Objective: To study the pathological characteristics of columnar alteration with prominent snouts and secretions (CAPSS) and its relationship with incidence of breast carcinoma. Methods: One hundred forty-four CAPSS specimens identified by breast core needle biopsies(CNB) were retrospectively evaluated. The CAPSS specimens were subdivided into lesions with (n=108) and without (n=36) atypical ductal hyperplasia and their pathological findings were compared. Results: In situ and invasive carcinomas were found in 21.5% (31/144) of the specimens, including those with and without atypical hyperplasia. We also found that specimens with atypical hyperplasia had a higher malignant incidence than those without atypical hyperplasia (P=0.001). Conclusion: CAPSS, especially when with atypical ductal hyperplasia, are associated with breast carcinoma.