Physicochemical properties of calcium phosphate cement incorporated with anti-tumor drugs / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 250-253, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-841170
ABSTRACT
Objective:
To study the influence of anti-tumor drug incorporation on the physicochemical properties of calcium phosphate cement(CPC).Methods:
Methotrexate (MTX), epirubicin (EPI), hydroxy camptothecin (OH-CPT), and arsenic trioxide (As2O3) were incorporated, each in a proportion of 2%, 5%, and 8%, into the powder-phase CPC. Untreated CPC was taken as control. The setting time, compression strength, and the microstructure of the resultant products were evaluated and tested.Results:
Compared with control group, the setting time was significantly prolonged when 2% EPI was incorporated into CPC (P<0.05), and the maximum compression strength was significantly decreased when 5% OH-CPT and 8% MTX, EPI were incorporated into CPC (P<0.05). Electron microscope showed no significant change in the crystal structure after incorporation of the drugs.Conclusion:
CPC is an ideal anti-tumor drug delivery material. The changes of physicochemical properties of CPC must be considered when anti-tumor drugs are incorporated into CPC for clinical application.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Academic Journal of Second Military Medical University
Ano de publicação:
2010
Tipo de documento:
Artigo
Similares
MEDLINE
...
LILACS
LIS