Auto-bone marrow mononuclear cells transplantation accelerates reendothelialization and inhibits neointima formation in vein grafts / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 16-18, 2010.
Artigo
em Chinês
| WPRIM
| ID: wpr-841215
ABSTRACT
Objective:
To assess the effect of auto-bone marrow mononuclear cells (BMMNCs) transplantation on reendothelialization and neointima formation in vein grafts.Methods:
BMMNCs were extracted from the bone marrows of adult rabbit under sterile environment and were labelled with DAPI before transplanted into vein grafts. Twenty adult rabbits were randomly divided into 2 groups BMMNCs transplantation group(group I, n 10) and PBS transplantation group (group II, n=10). The left external jugular vein of 20 rabbits were harvested and transplanted between ipsolateral common carotid artery (AVG). Three days later, animals in group I were transplanted with BMMNCs(6x108 cells)/100 μl via periotic veins and those in group II were injected with 100 μl PBS. Animals were killed 4 weeks later and graft veins were harvested to observe the reendothelialization and the thickness of vein grafts.Results:
We found that the transplanted cells survived and were incorporated into the endothelium of vein grafts in group I. The endothelium integrity of the vein grafts in group I was significantly better than that of group II. The intima thickness of vein grafts in group I was significantly thicker than that of group II.Conclusion:
BMMCs transplantation therapy may improve re-endothelialization of the vein graft and inhibits intimal hyperplasi the vein graft.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Academic Journal of Second Military Medical University
Ano de publicação:
2010
Tipo de documento:
Artigo
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