Therapeutic effect of oat β-glucans on serum lipid levels of rats with experimental hyperlipemia / 第二军医大学学报
Academic Journal of Second Military Medical University
;
(12): 510-513, 2006.
Artigo
em Chinês
| WPRIM
| ID: wpr-841421
ABSTRACT
Objective:
To investigate the therapeutic effect of oat β-glucans on serum lipid levels of rats with experimental hyperlipemia.Methods:
Rats were fed on high fat forage for 3 weeks to establish hyperlipemia models, then the model rats were orally given oat β-glucans at doses of 133, 266 and 533 mg/(kg · d) separately. At the same time, there were 3 control groups including chitosan ligosaccharide[200 mg/(kg · d)], normal, and high blood lipid (model rats fed with distilled water). Serum levels of total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were assayed in rats of all groups and the results were compared.Results:
β-glucans obviously decreased the levels of TC and LDL-C and increased HDL-C in rat hyperlipemia models. The reduction of serum lipid level in 4-week β-glucans treatment rats was more obvious than that in 3-week β-glucans treatment rats. Besides, β-glucans showed an obvious dosage dependent effect in reducing serum lipid level without adverse effect. Oat β-glucans had a better lipid-reducing effect than ligosaccharide did.Conclusion:
Oat β-glucans can obviously decrease serum lipid in rats with hyperlipemia.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Academic Journal of Second Military Medical University
Ano de publicação:
2006
Tipo de documento:
Artigo
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