Values of IL-27 and IFN-γ in pleural effusion in diagnosis of tuberculous pleuritis / 吉林大学学报(医学版)

ABSTRACT

Objective: To detect the levels of interleukin-27 (IL-27) and interferon-γ (IFN-γ) in pleural effusion, and to explore the values of IL-27 and IFN-y in the diagnosis of tuberculous pleuritis. Methods: A total of 88 patients with pleural effusion were selected and divided into tuberculous pleural effusion (TPE) group (n = 4 4), malignant pleural effusion group (n = 2 0), parapneumonia pleural effusion group (n = 12), and transudative pleural effusion group (n = 1 2) . The levels of IL-27, IFN-y and adenosine deaminase (ADA) in pleural effusion of the patients in various groups were detected; the receiver operating characteristic (ROC) curve was drawn to evaluate their diagnostic values for tuberculous pleuritis. Results: The levels of IL-27 and IFN-γ in pleural effusion of the patients in TPE group were significantly higher than the other three groups (P < 0 . 05). The areas under ROC curve (AUC) of IL-27, IFN-γ and ADA in pleural effusion in diagnosis of tuberculous pleuritis were 0. 96, 0. 79 and 0. 92, respectively; the specificities were 94. 4%, 89. 5% and 92. 1%, respectively; the sensitivities were 100%, 61. 4% and 78. 6%, respectively. The specificity (97. 4%) of combined detection of IL-27, IFN-γ and ADA was higher than those of single detection. Conclusion: The levels of IL-27, IFN-γ and ADA in pleural effusion can be used as an effective method to the differential diagnosis of tuberculous pleuritis. Detection of IL-27 in pleural effusion has a higher diagnostic value for tuberculous pleuritis than IFN-γ and ADA. Combined detection of IL-27, IFN-y and ADA has the important value in the diagnosis of tuberculous pleuritis.