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Expressions of HIF-1α and HSP70 in placenta tissue of patients with pregnancy-induced hypertension syndrome and their significances / 吉林大学学报(医学版)
Journal of Jilin University(Medicine Edition) ; (6): 346-349, 2018.
Artigo em Chinês | WPRIM | ID: wpr-841931
ABSTRACT

Objective:

To investigate the expressions of hypoxia-inducible factor-la (HIF-la) and heat shock protein 70 (HSP70) in the placenta tissue of the patients with pregnancy-induced hypertension syndrome (PIH), and to elucidate the clinical significances of their expressions in the placenta tissue of the patients with PIH.

Methods:

Twenty-two cases of placenta tissue of the PIH patients (PIH group) and eighteen cases of placenta tissue of the normal pregnant women (control group) were selected. The expressions of HIF-la and HSP70 were detected by immunohistochemical method. The differences of potive expressions rates of HIF-la and HSP70 in placenta tissue of the PIH patients and the normal pregnant women and their relationships in placenta tissue of the PIH patients were analyzed.

Results:

The positive expression rate of HIF-1α in placenta tissue of the patients in PIH group (81.8%) was higher than that of the normal pregnant women in control group (38.9%) (χ2=7.785, P= 0.005), and the positive expression rate of HSP70 in placenta tissue of the patients in PIH group 90.9%) was higher than that of the normal pregnant women in control group 55.6%) (χ2=6.599, P=0.010). Eighteen cases of placenta tissue with HIF-la positive expression in the PIH patients had HSP70 positive expression (100.0%); among four cases of placenta tissue with HIF-la negative expression, two cases had HSP70 negative expression 50.0%); their expressions in placenta tissue of the PIH patients had positive correlation (r=0.671, P=0.001).

Conclusion:

The expressions of HIF-la and HSP70 in placenta tissue of the PIH patients are higher, and they have positive correlation.

Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Journal of Jilin University(Medicine Edition) Ano de publicação: 2018 Tipo de documento: Artigo

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Texto completo: DisponíveL Índice: WPRIM (Pacífico Ocidental) Idioma: Chinês Revista: Journal of Jilin University(Medicine Edition) Ano de publicação: 2018 Tipo de documento: Artigo