Study on Integral Dissolution Model Based on Biological Potency for Compound Chinese Materia Medica / 中草药·英文版
Chinese Herbal Medicines
;
(4): 143-149, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-842267
ABSTRACT
Objective:
To investigate the integral dissolution model based on biological potency in order to evaluate the dissolution of Compound Chinese materia medica (CCMM) in vitro.Methods:
The contents of paeoniflorin, phillyrin, ginsenoside Rg1, and adenosine of ten batches of Compound Biejia Ruangan Tablet (CBRT) were determined at different times. The self-defined weighting coefficient based on the contents has been created to establish the integral dissolution model. In addition, the biological potency of CBRT was measured by MTT assay. Then, the f2 similar factor was used to evaluate the similarity of the batches.Results:
Compared with batch a, some batches' f2 values of paeoniflorin and adenosine were less than 50, while f2 values of ginsenoside Rg1, phillyrin, and integral component were more than 50. Likewise, ginsenoside Rg1, phillyrin, and integral component were all in good correlation with biological dissolution.Conclusion:
The results of the integral dissolution based on biological test of CBRT demonstrate that the bioassay method may be a promising supplement for its quality evaluation.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
Idioma:
Chinês
Revista:
Chinese Herbal Medicines
Ano de publicação:
2015
Tipo de documento:
Artigo
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