A Novel Bihomoflavanonol with an Unprecedented Skeleton from Pteridium aquilinum / 中草药·英文版
Chinese Herbal Medicines
;
(4): 96-100, 2014.
Artigo
em Chinês
| WPRIM
| ID: wpr-842386
ABSTRACT
Objective:
To seek the flavonoids with the unique structure and to investigate the chemical ingredients in the flavonoid-rich plant- Pteridium aquilinum.Methods:
The 80% EthOH extract from the degreased powder of P. aquilinum was partitioned by petroleum ether, CHCl3, EtOAc, n-butanol, and water, respectively. The EtOAc fraction was sequentially subjected to silica gel column, repeated Sephadex LH-20 column, and preparative TLC to give a new compound. The antitumor activity of the novel flavonoid was primarily evaluated by MTT.Results:
Compound 1, a biflavonoid with the unique structure named as pteridium III with an unprecedented bihomoflavanonol skeleton, was isolated from P. aquilinum. Compound 1 showed the in vitro antitumor activity against lung cancer cell NCI-H46, melanoma cell A375, and glioma cell U-7MG corresponding to the IC50 values of 22.9, 106.7, and 1540.5 μmol/L, respectively. No inhibition on gastric carcinoma SGC-7901 and prostatic carcinoma PC-3 was observed in the experiment.Conclusion:
A rare bihomoflavononol derivative, pteridium III, is obtained from the plant, which could enrich our knowedge on the chemical structures of flavonoids and bioactive constituents in P. aquilinum. © 2013 Tianjin Press of Chinese Herbal Medicines.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Herbal Medicines
Ano de publicação:
2014
Tipo de documento:
Artigo
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