Immunomodulatory effect of myeloid-derived suppressor cell and its impact on tumor therapy / 上海交通大学学报（医学版）

ABSTRACT

Myeloid-derived suppressor cells (MDSCs) are a group of cells with potent immune suppressive activity which have emerged as an important contributor to tumor progression and genesis. More and more clinical researches have found that accumulation of MDSCs in peripheral blood and tumor tissues could predict dismal outcome for patients with malignancies, which was a potential prognostic tumor marker. In addition, immunosuppression induced by MDSCs could reduce the efficacy of anti-tumor therapies. Therefore, better understanding the mechanism of MDSCs’ immune suppression in tumor microenvironment can provide reference for exploring new immunotherapies.