Relationship between serum uric acid level and subclinical target organ damage / 上海交通大学学报（医学版）

ABSTRACT

Objective: To explore the correlation between serum uric acid level and subclinical target organ damage. Methods: A cohort of 333 patients were recruited at the Department of Examination Center of Ruijin Hospital North in July 2017, who were divided into two groups, normal (n=248) and high levels (n=85, males >420 µmol/L, females >360 µmol/L) of serum uric acid. Subclinical target organ damage indexes included glomerular filtration rate (eGFR), left ventricular mass index (LVMI) and other indicators. Results: Systolic pressure (P=0.006), diastolic pressure (P=0.000), serum creatinine (P=0.000) and LVMI (P=0.028) in the high uric acid group were significantly higher than those in the normal uric acid group, and eGFR was significantly lower than that of the control group (P=0.000). Pearson correlation analysis showed that the serum uric acid level was significantly correlated with systolic pressure (r=0.149, P=0.007), diastolic pressure (r=0.269, P=0.000), LVMI (r=0.172, P=0.002) and serum creatinine (r=0.569, P=0.000), and negatively correlated with glomerular filtration rate (r=-0.383, P=0.000). After adjusting to sex, age, and BMI, there was a significant positive correlation with diastolic pressure (r=0.170, P=0.013), and a significant negative correlation with glomerular filtration rate (r=-0.332, P=0.000). After further adjusting to blood pressure, there was a significant negative correlation with glomerular filtration rate (r=-0.291, P=0.000). Multivariate linear regression analysis showed that serum uric acid was independent of diastolic pressure and glomerular filtration rate (β=0.162, P=0.000; β=-0.058, P=0.004). Conclusion: Serum uric acid is positively correlated with diastolic blood pressure, and is negatively correlated with glomerular filtration rate.