Research progress of NLRP3 inflammasome in the pathogenesis of depression disorder / 上海交通大学学报（医学版）

ABSTRACT

Depression disorder is a kind of serious mental illness which poses high health risks and heavy financial burden to individuals and the society. Currently, there are many theories on the pathogenesis of depression disorder, such as neurotransmitter disorders, endocrine disorders, abnormal neuronal adaptability and plasticity, oxidative stress and mitochondrial dysfunction and so on. In the lately decade, the research of immune dysfunction in the pathogenesis of depression has become a newly hot-point. This review summarizes NLRP3 inflammasome in the pathogenesis of depression disorder.