Temozolomide resistance in high grade gliomas / 上海交通大学学报(医学版)
Journal of Shanghai Jiaotong University(Medical Science)
; (12): 117-124, 2018.
Article
em Zh
| WPRIM
| ID: wpr-843811
Biblioteca responsável:
WPRO
ABSTRACT
High grade gliomas are always the research focus in the field of neurosurgery due to their poor prognosis despite the current standard therapeutic regimen of surgical resection followed by radiation therapy and chemotherapy. Alkylating agent temozolomide has been established as the standard chemotherapy while its resistance inevitable during treatment. This phenomenon seriously influences the prognosis of patients suffering from high grade gliomas. This review aims to elucidate temozolomide chemoresistance mechanisms through three chapters including O6-methylguanine-DNA methyltransferase (MGMT) methylation, mismatch repair mutation and epigenetic regulation consisting of p21, chromatin and histone, Y-box binding protein-1 and microRNAs.
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WPRIM
Idioma:
Zh
Revista:
Journal of Shanghai Jiaotong University(Medical Science)
Ano de publicação:
2018
Tipo de documento:
Article