Correlation of Survivin gene and UHRF1 gene expressions with sensitivity to cervical cancer in cervical cancer / 西安交通大学学报(医学版)

ABSTRACT

Objective: To study the expressions of Survivin mRNA and UHRF1 mRNA in cervical cancer tissues and their relationship with radiosensitivity to cervical cancer. Methods We recruited 112 patients with cervical cancer who underwent radical radiotherapy in our hospital. The expression levels of tumor Survivin mRNA and UHRF1 mRNA were detected by RT-PCR. We analyzed the correlation of expression levels of Survivin mRNA and UHRF1 mRNA, as well as clinical characteristics such as age, stage, tumor differentiation and tumor diameter with radiosensitivity. The independent predictors related to radiosensitivity were analyzed by Logistics. Results: After radiotherapy in 112 patients with cervical squamous cell carcinoma, 48 patients received radiotherapy and 64 patients received radiotherapy. Compared with radiosensitivity group, the degree of differentiation was lower and the tumor diameter was larger, and the expression levels of Survivin mRNA and UHRF1 mRNA were higher in the radioresistance group (P0.05), but Univariate and multivariate logistic analysis showed that Survivin mRNA and UHRF1 mRNA expression levels were the independent predictors of radiosensitivity in the cervical cancer patients. Patients with low expressions of Survivin mRNA and UHRF1 mRNA had higher sensitivity to radiotherapy. Conclusion: The expressions of Survivin mRNA and UHRF1 mRNA are negatively correlated with the sensitivity to cervical squamous cell carcinoma. The lower the expression, the higher the sensitivity of radiotherapy.