Effects of sodium and potassium intervention on adult plasma levels of pentraxin-3 / 西安交通大学学报(医学版)
Journal of Xi'an Jiaotong University(Medical Sciences)
;
(6): 679-683, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-843966
ABSTRACT
Objective:
To explore the responses of plasma pentraxin-3 (PTX-3) to sodium and potassium supplementation so as to investigate the potential role of PTX-3 in salt-induced hypertension.Methods:
We enrolled 48 volunteer participants from Liquan County, Shaanxi Province. All the subjects sequentially went through a 3-day normal diet, a 7-day low-sodium diet, a 7-day high-sodium diet, and a 7-day high-sodium plus potassium diet. Plasma concentration of PTX-3 was assessed by ELISA.Results:
Subjects with lower PTX-3 tended to have higher body mass index (BMI), diastolic blood pressure (DBP), and mean arterial pressure (MAP). PTX-3 was negatively correlated with BMI, DBP, and MAP. During low-salt period, plasma PTX-3 significantly decreased compared with the baseline [(0.57±0.19)ng/mL vs. (0.72±0.33)ng/mL, P=0.012], but elevated during high-salt period [(0.68±0.26)ng/mL vs. (0.57±0.19)ng/mL, P=0.037]. Potassium supplementation significantly inhibited the salt-induced increase of PTX-3 [(0.56±0.21)ng/mL vs. (0.68±0.26)ng/mL, P=0.015]. PTX-3 was positively correlated with the sodium-to-potassium ratio (r=0.230, P=0.002). The response of PTX-3 was more prominent in salt-sensitive subjects.Conclusion:
Dietary sodium and potassium interventions significantly affect circulating PTX-3. Low-salt intake contributes to the decrease of plasma PTX-3 while PTX-3 increases after high-salt intake. Potassium supplementation can inhibit salt-induced increase of PTX-3.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of Xi'an Jiaotong University(Medical Sciences)
Ano de publicação:
2019
Tipo de documento:
Artigo
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