Relationship between clinical features and cognitive function of patients with schizophrenia / 西安交通大学学报(医学版)

ABSTRACT

Objective: To investigate the relationship between the 5 Positive and Negative Syndrome Scale (PANSS) factors of a recent consensus model and cognitive performance in patients with schizophrenia. Methods: Totally 130 inpatients and 85 healthy controls matched for age, gender and education were recruited. The MATRICS Consensus Cognitive Battery (MCCB) was used to evaluate cognitive function. PANSS was used to evaluate symptoms. Results: Compared with those of the controls, scores of TMT, BACS, Fluency, WMS, HVLT-R, BVMT-R, NBA and MSCEIT tests in MCCB were lower in the patients (all P<0.001). The PANSS cognitive factor showed a small to moderate significant association with MCCB speed of processing, verbal learning, reasoning and problem solving and social cognition (all P<0.050). Notably, however, no relationship was found between the other PANSS factors and any of the MCCB scores. Conclusion: There are a wide range of cognitive function impairments in patients with schizophrenia. These results support the relative independence of cognition from other domains of psychopathology, including negative symptoms, in patients with schizophrenia. Therefore, we need to make different kinds of plans when treating patients.