Effects of moxibustion on serum cytokines in experimental animals with rheumatoid arthritis: a systematic review and meta-analysis / 针刺研究
Acupuncture Research
;
(6): 751-761, 2020.
Artigo
em Chinês
| WPRIM
| ID: wpr-844105
ABSTRACT
OBJECTIVE:
To systematically review the effects of moxibustion on serum cytokines in experimental animals with rheumatoid arthritis.METHODS:
PubMed, Embase, Web of Science, The Cochrane Library, CNKI, VIP, Wanfang Data, and CBM were searched for animal experiments on moxibustion intervention for rheumatoid arthritis. Related data were extracted, and RevMan 5.3 was used to perform a meta-analysis of outcome measures, including serum tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-6 (IL-6), vascular endothelial growth factor (VEGF), interleukin-17 (IL-17), interleukin-2 (IL-2), interferon-γ (IFN-γ), receptor activator of nuclear factor-kappa B ligand (RANKL), transforming growth factor-β (TGF-β), and degree of swelling of diseased joint.RESULTS:
A total of 18 studies were included. The detection methods included radioimmunoassay and ELISA and the experimental animal species included rats and rabbits. The studies on serum TNF-α and degree of swelling of diseased joint had publication bias. Meta-analysis showed that the moxibustion group had significant reductions in the serum levels of TNF-α, IL-1, IL-2, IL-6, VEGF, IL-17, and RANKL, significant increases in the serum levels of TGF-β and IFN-γ, and a significant reduction in the degree of swelling of diseased joints in model animals.CONCLUSION:
Moxibustion can effectively regulate levels of the serum cytokines in experimental animals of rheumatoid arthritis and thus reduce inflammatory response and alleviate the swelling of diseased joints.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Tipo de estudo:
Estudo prognóstico
/
Revisões Sistemáticas Avaliadas
Idioma:
Chinês
Revista:
Acupuncture Research
Ano de publicação:
2020
Tipo de documento:
Artigo
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