Analysis of volatile components of the different Jiuwei Qianghuo preparations by HS-SPME-GC-MS and principal component analysis / 国际药学研究杂志

ABSTRACT

Objective: To analyze and compare the volatile components of Jiuwei Qianghuo pills, granules and oral liquid. Methods: The volatile components of Jiuwei Qianghuo pills, granules and oral liquid were analyzed and compared by the head-space solid-phase microextraction and gas chromatography-mass spectrometry(HS-SPME-GC-MS), the relative percentage of each component was calculated using the area normalization method, and the principal component analysis was also performed. Results: A total of 90 kinds of volatile components were identified from Jiuwei Qianghuo pills, accounting for 97.19% of the total volatile components; 27 kinds of volatile components were identified from Jiuwei Qianghuo granules, accounting for 92.92% of the total volatile components;22 kinds of volatile components were identified from Jiuwei Qianghuo oral liquid, accounting for 87.60% of the total volatile components. A total of 111 volatile components were identified in the three preparations, of which 6 were common components, but the contents of the common components were different. The specific components of the pills, granules and oral liquid were 68, 8 and 13, respectively. Moreover, the comprehensive scores of the three dosage forms in the principal component analysis showed a large difference, with the high, middle and low values for the pills, granules and oral liquid, respectively. Conclusion: The composition and content of volatile components were different in the Jiuwei Qianghuo pill, granule and oral liquid preparations. From the point of view of the volatility, the comprehensive score of Jiuwei Qianghuo pills is higher than that of granules and oral liquid.