Survey on pathogens of co-infection of influenza virus pneumonia among adults in Beijing from 2015 to 2018 / 国际药学研究杂志

ABSTRACT

Objective: To analyze the co-infection of influenza virus infection pneumonia in Beijing from 2015 to 2018, so as to provide reference for the selection of clinical antibiotics and antiviral drugs. Methods: The 114 influenza virus positive samples were screened out from the influenza virus infected pneumonia samples collected from 23 hospitals in Beijing from January 2015 to December 2018, of which 77 were severe pneumonia. Co-infection of 12 viruses and 11 bacteria in the respiratory tract was detected by fluorescence quantitative PCR. Results: Of the 114 patients with influenza pneumonia, only 22 cases(19.3%)with influenza virus infection were detected, of which 18 cases(15.8%)were infected with influenza A virus and 4 cases(3.5%)were infected with influenza B virus. A total of 92 cases(80.7%)of influenza virus mixed with other pathogens, including 47 cases(51.1%)co-infected with one pathogen, 45 cases(48.9%)co-infected with multiple pathogens Among the cases, influenza A virus and influenza B virus co-infected the most(8.5%); 42 cases(89.4%)were co-infected with bacteria, of which the highest infection rate was methicillin-resistant Staphylococcus aureus, followed by pneumonia Streptococcus and Pseudomonas aeruginosa. Conclusion: More than 80% of patients with severe viral pneumonia of influenza have co-infection of influenza virus and bacteria. The bacterial pathogens co-infected with influenza virus and bacteria in Beijing area from 2015 to 2018 are methicillin-resistant Staphylococcus aureus> Streptococcus pneumoniae> Verdigris Pseudomonas, among which methicillin-resistant Staphylococcus aureus is the most common bacteria co-infected with influenza virus in Beijing in recent years. The results of this study provide a reliable basis for clinical treatment drug screening.