Research progress of natural marine product macrosphelides / 国际药学研究杂志
Journal of International Pharmaceutical Research
;
(6): 899-911, 2019.
Artigo
em Chinês
| WPRIM
| ID: wpr-845220
ABSTRACT
This paper summarizes the natural macroephelides,including the preparation of three key segments and the synthesis of 16-or 15-membered macrolactone skeleton by the ring-closing metathesis(RCM)strategy. It also summarizes the synthetic approaches to macrosphelide derivatives,including the common pharmaceutical chemistry methods,such as the ring size modification,the modification of lateral groups on the macro ring,and the combinatorial chemistry approach. Additionally,a brief introduction of structure-activity relationships is given for related compounds.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of International Pharmaceutical Research
Ano de publicação:
2019
Tipo de documento:
Artigo
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