Protective effect of propofol on total body irradiation induced hematopoietic system injury in mice / 国际药学研究杂志

ABSTRACT

Objective To observe the protective effect of propofol on hematopoietic system injury in mice with total body irradiation (TBI). Method Three different radiation doses were used in the experiments: 7.5 Gy TBI in 30 day-survival experiment, 6Gy TBI in colony-forming unit spleen (CFU-S) experiment and 2Gy TBI in the other experiment; mice were divided into 4 groups in a 30 day-survival experiment, including 7.5Gy TBI group, 7.5 Gy TBI + 5 mg/kg propofol group, 7.5 Gy TBI + 10 mg/kg propofol group and 7.5 Gy TBI + 20 mg/kg propofol group. For the other experiments, mice were divided into 4 groups: control group, propofol group, TBI (2 or 6 Gy) group, and TBI + 20 mg/kg propofol group. Propofol of 20 mg/kg were administered to mice 1 d before TBI, 30 mins before TBI and once each day within the following 7 days after TBI. Mice were euthanized on the ninth day after TBI, the number of CFU-S, peripheral blood parameters and bone marrow cells per femur were measured in this experiment. Results Propofol improved the 30 day-survival of lethally irradiated mice. There were increases in number of CFU-S, white blood cells, red blood cells, hemoglobin in peripheral blood and bone marrow cells per femur in 2 Gy TBI + 20 mg/kg propofol group compared to 2 Gy TBI group (P<0.05). Conclusion Propofol exhibits a promising protective effect on TBI-induced hematopoietic system injury; further study should be focused on the related mechanisms.