Optimization of artemether self-microemulsifying drug delivery system by central composite design-response surface methodology / 国际药学研究杂志

ABSTRACT

Objective To optimize and assess the formulation of self-microemulsifying drug delivery systems (SMEDDS) for artemether(ARM). Methods The optimized formulation of ARM-SMEDDS was screened by solubility, ternary phase diagram and central composite design-response surface methodology, with the particle size, Zeta potential and solubility as parameters. The physicochemical property and dissolution characters of ARM-SMEDDS were also determined. Results The optimized SMEDDS was composed of Cremophor RH40 (39.29%), Transcutol HP (35.71%) and MCT(25%). The average particle size after the emulsification was 24.52 nm, the Zeta potential was-10.10 mV, and the drug loading of self-microemulsifying exceeded 88 mg/g. Conclusion The optimized formulation of ARM-SMEDDS using the star point design-response surface methodology has significantly enhanced the solubility and in vitro dissolution of ARM.