Orally disintegrating tablets based on lyophillization technology : Research advances / 国际药学研究杂志

ABSTRACT

The orally disintegrating tablets (ODT) are the kinds of novel oral dosage forms which begin to gain popularity and acceptance since they can disintegrate/dissolve quickly in the oral cavity upon contact with saliva, resulting in solutions or suspensions form of the administered medicine. The ODTs are perfect alternative for pediatric and geriatric patients with difficulty in swallowing, and uncooperative patients because of their convenience of self-administration and compactness. This communication reviews the applications and technologies involved in formulation feature, lyophillization process, excipients selection, fast dissolving mechanism, and determination of disintegration time.