Synthesis of isavuconazonium sulfate: Research advances / 国际药学研究杂志
Journal of International Pharmaceutical Research
;
(6): 436-440, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-845539
ABSTRACT
Isavuconazole is a broad-spectrum triazole antifungal agent, which is administered as a water-soluble prodrug-isavuconazonium sulfate. Recently, its oral and intravenous formulations are available. Isavuconazole inhibits fungal cytochrome P45014DM, thus interferes with the biological function of cell wall formation and plays the antifungal role. In this paper, we summarize the synthetic methods of isavuconazole, water-soluble segments of side chain and isavuconazonium sulfate and evaluate their advantages and disadvantages, which lays a foundation for isavuconazonium sulfate technology development.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of International Pharmaceutical Research
Ano de publicação:
2016
Tipo de documento:
Artigo
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