Synthesis and evaluation of new 3-aminooxazolidin-2-one derivatives for inhibiting bacterial quorum sensing / 国际药学研究杂志
Journal of International Pharmaceutical Research
;
(6): 476-480, 2016.
Artigo
em Chinês
| WPRIM
| ID: wpr-845546
ABSTRACT
Objective To develop some 3-aminooxazolidin-2-one derivatives with bacteria quorum sensing(QS) inhibitory activity. Methods Using (2-hydroxyethyl) hydrazine as raw material, we finished the synthesis through cyclization, condensation, hydrolysis and condensation reaction, and evaluated their inhibition of QS via Chromobacterium violaceum. Results Eight compounds were synthesized and their structures were confirmed by 1H NMR and MS characterization. Compounds Z2 had inhibitory effect against QS. Conclusion None of the eight synthesized compounds have been reported before and the synthetic route is reliable. Compounds Z2 have inhibitory effect against QS.
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Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of International Pharmaceutical Research
Ano de publicação:
2016
Tipo de documento:
Artigo
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