Composite phospholipids liposomes: research advances / 国际药学研究杂志

ABSTRACT

Liposomes are a kind of common drug delivery system in pharmaceutics. They can be used as the dosage form of water insoluble drugs to improve their bioavailability. However, these traditional liposomes have some disadvantages such as low encapsulation efficiency, instability and drug leakage in a long term of storage, which have limited the development of dosage form products based on liposomes. Recently, a novel kind of liposomes, namely composite phospholipids liposomes, has been devel-oped. Compared to traditional liposomes, composite phospholipids liposomes have a very promisingly application prospect due to their advantages including higher encapsulation efficiency and drug-loading efficiency, good stability and no drug leakage. This article re-viewes the research progress in the composite phospholipids liposomes, including their composition, structure, preparation method, function property and recent application in pharmaceutics.