Molecular differences between recombinant coagulation factors and plasma-derived coagulation factors, and their effects on pharmacology and efficacy / 国际药学研究杂志
Journal of International Pharmaceutical Research
;
(6): 131-142, 2015.
Artigo
em Chinês
| WPRIM
| ID: wpr-845665
ABSTRACT
Since their successful launch, the recombinant coagulation factors have been effective in the treatment and prophylaxis of respective deficiencies, and started to replace plasma-derived coagulation factors. However, immunogenicity and induction of inhibitors associated with the uses of these recombinant products have drawn certain attention. This manuscript reviews the structural differences between several major recombinant coagulation factors and their plasma-derived counteiparts, including sequences and many forms of post-translational modifications, and discusses the possible effects of these structural differences on the pharmacology, efficacy and pharmacokinetics of the products. The demonstration of structural differences and underlying mechanisms helps to improve the production yield and quality of recombinant coagulation factors, which is of significant clinical importance.
Texto completo:
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Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of International Pharmaceutical Research
Ano de publicação:
2015
Tipo de documento:
Artigo
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