Cholinergic anti-Inflammatory pathway:Research advances / 国际药学研究杂志

ABSTRACT

The cholinergic anti-inflammatory pathway regulates the inflammation response to injury, pathogens, tissue ischemia et al, by stimulating the peripheral vagus or centrally acting muscarinic agonists. It can regulate the systemic inflammation rapidly and directly, and inhibit the lethal effect of biotoxins (e.g, lipopolysaccharide). Based on the recent advancements, the historical origins and constitution of the cholinergic anti-inflammatory pathway, the connection between vagus and spleen, and the relationship with the inflammatory reflex are summarized.