Progress on the second generation inhibitors of hepatitis C virus NS3/4A serine protease / 国际药学研究杂志
Journal of International Pharmaceutical Research
;
(6): 14-19, 2013.
Artigo
em Chinês
| WPRIM
| ID: wpr-845871
ABSTRACT
The progress of the second generation inhibitors of HCV NS3/4A serine protease, based on the modifications to the first generation ones (telaprevir, boceprevir, BILN-2061), is reviewed. The second generation inhibitors can significantly improve potency, pharmacokinetic profiles, and to some degree reduce the resistance induced by the first generation ones. The structure-activity relationships of these inhibitors are also discussed.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of International Pharmaceutical Research
Ano de publicação:
2013
Tipo de documento:
Artigo
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