Development of inhibitors against dengue virus / 国际药学研究杂志

ABSTRACT

Dengue virus (DENV) infections constitute one of the most prevalent infectious diseases worldwide, causing millions of infections annually. No antiviral therapy or vaccine is currently available for the treatment of DENV infection. In recent years, considerable studies on inhibitors of DENV have been done. In this review, we present recent progresses for development of DENV inhibitors. The inhibitors against viral protease and polymerase, host factors involved in virus replication, virus entry, and oligonucleotide antiviral inhibitors such as antisense agents and small interfering RNA are summarized.