Clathrin-mediated endocytosis and broad-spectrum antivirals / 国际药学研究杂志

ABSTRACT

Viral disease is a serious threat for human health. Alhough plenty of antiviral agents have been used in clinical treatment, many viruses are resistant to them via virus mutation. And novel harmful viruses emerge in endlessly. So research and development of new antiviral drugs, especially the agents that are of broad-spectrum antiviral activity is particularly important. Clathrin-mediated endocytosis is the most common pathway used by viruses and pathogens for entering host cells. The inhibitors of clathrin-mediated endocytosis may block the entry of viruses and pathogens, thus prevent viral infection. For the inhibitors do not directly act on the virus itself, it is hard to induce virus mutations which produce drug resistance. Clathrin-mediated endocytosis is the potential target of broad-spectrum antiviral agents inrecent years. This review focuses on the mechanism of virus entry through clathrin-mediated endo-cytosis the recent advances of clathrin-mediated endocytos is inhibitors and their potential applications in broad-spectrum antiviral ther-apeutics field.