DNA, RNA G-quadruplcx and their small molecular ligands: Research advances / 国际药学研究杂志
Journal of International Pharmaceutical Research
;
(6): 358-367, 2012.
Artigo
em Chinês
| WPRIM
| ID: wpr-845892
ABSTRACT
In recent years, G-quadruplexes overexpression has been found in different biologically significant regions, such as oncogene-promoter regions, human telomeres DNA and mRNA 5'-untranslated region(lJTR). Therefore, a novel anticancer strategy may be developed by searching some ligands to stabilize or to induce the G-quadruplexs so as to inhibit cancer gene transcription and traaslation process. The current structural database of folding topologies. The anticancer mechanism taigeting different types of G-quadruplex, and the progresses on the corresponding small molecular ligands as potent antitumor agents are summarized in this review. © 2006 Editorial office of Foreign Medical Sciences.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Journal of International Pharmaceutical Research
Ano de publicação:
2012
Tipo de documento:
Artigo
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