Antidepressant-like effect of a novel compound YL-0919, a dual 5-HT 1A agonist and serotonin reuptake inhibitor / 国际药学研究杂志

ABSTRACT

Objective: To evaluate the antidepressant-like effect on animal models of a novel compound YL-0919, a dual 5-HT1A agonist and serotonin reuptake inhibitior. Methods: Using the tail suspension test, the forced swimming test and the locomotor activity test in mice, and the learned helplessness test in rats,the antidepressant-like effect of YL-0919 (0.625,1.25,2.5 and 5.0 mg/kg) were evaluated. Results: In the tail suspension test and the forced swimming test in mice, intragastric administration of YL-0919 (0.625-2.5 mg/kg) significantly decreased the immobility time. And in this dose range YL-0919 did not influence the locomotor activity in mice. In the learned helplessness test in rats,YL-0919 (0.625-1.25 mg/kg per day,once a day for 4 days) significantly decreased the numbers of escape failure. Conclusion: YL-0919 produced reliable antidepressive effect on the three animal models in the dose without stimulant or inhibitive effect on behaviors. And no excite or inhibition effect of YL-0919 on central nerve systems was observed. These results suggest that YL-0919 have the potential foreground as a novel antidepressant.