Applications of antisense technology in discovery and development of novel antibacterial drugs / 国际药学研究杂志

ABSTRACT

Antibiotic-resistance has become a serious problem to human health. Innovative approaches are urgently required for both antimicrobial drug discovery and reversal of resistance. Great success has been achieved since the introduction of antisense technology. This review focuses on the applications of antisense technology in the aspects including identification and validation of novel antibacterial drug targets, screening of antibacterial drugs from natural products using hypersensitized strains engineered by inducible antisense RNA, and inhibition of antibiotic-resistance genes to reverse susceptibility of antibiotic-resistant strains to currently used antibiotics. In addition, the antibacterial activities, the shortcomings and prospects as antibacterial drugs of synthetic antisense oligodeoxynucleotides and their analogs are also assessed in this review.