A new lactone from Euscaphis konishii / 中草药

ABSTRACT

Objective: To study the chemical constituents of Euscaphis konishii. Methods: The chemical constituents from 95% EtOH extract of the stems of E. konishii were isolated by repeated chromatograph with silica gel, Sephadex LH-20 and semi-preparative RP-HPLC. The structure of the separated chemical components was identified by modern spectroscopy identification. Results: Eight compounds were isolated from the ethyl acetate fraction of 95% EtOH extract of E. konishii, and identified as 4 (R)-(4'-hydroxybenzoyl) dihydrofuran-2(3H)-one (1), 6-hydroxymellein (2), euscapholide (3), dehydrovomifoliol (4), ethyl gallate (5), tetraketide (6), p-hydroxybenzoic acid (7) and nicotinic acid (8). Conclusion: Except for compounds 3 and 6, they are all isolated for the first time in this genus, and all compounds are isolated for the first time in this plant. Among them, compound 1 is a new compound named konieuscaphide.