Formulation optimization of andrographolide self-nanoemulsifying drug delivery system and effect of precipitation inhibitor on its phase behavior / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 4160-4168, 2020.
Artigo
em Chinês
| WPRIM
| ID: wpr-846228
ABSTRACT
Objective:
To investigate the effect of HPMC, PVP k30 and PEG 4000 on the phase behavior of andrographolide self-nanoemulsifying drug delivery system (AG-SNEDDS) dispersed in Fasted-state simulated intestinal fluid (FaSSIF).Methods:
The preparation technology of andrographolide AG-SNEDDS was optimized by central composite design. The effect of three types of precipitation inhibitors (PVP-k30, HPMC, PEG 4000) on the supersaturation behavior of AG-SNEDDS dispersed in FaSSIF was investigated with the degree of supersaturation as an evaluation index. The precipitated phase was evaluated by polarized light microscopy (PLM).Results:
The results showed that the best prescription of AG-SNEDDS was Capryol 90-Cremophor ELTween-20 (11)-Transcutol HP (12.940.546.6). The self-microemulsion was uniform, the drug loading was (6.93 ± 0.04) mg/g. The emulsification time was (22.33 ± 0.33) s, the average particle size was (14.25 ± 0.65) nm. HPMC and PEG 4000 can maintain the supersaturation of AG-SNEDDS after being dispersed in FaSSIF, and the effect was positively correlated with their concentration. As for PVP k30, it reduced the degree of supersaturation at a low concentration, but can maintain supersaturation at medium and high concentration. Using any of the three precipitation inhibitors can reduce the particle size of the precipitated particles.Conclusion:
Precipitation inhibitors can maintain the supersaturation of AG when disperse AG-SNEDDS in FaSSIF. The ability to maintain supersaturation varies with the types and concentration of precipitation inhibitor.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Traditional and Herbal Drugs
Ano de publicação:
2020
Tipo de documento:
Artigo
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