Study on mechanism of berberine on regulating glycogen metabolism by repairing glycogen structure / 中草药
Chinese Traditional and Herbal Drugs
;
(24): 4259-4265, 2020.
Artigo
em Chinês
| WPRIM
| ID: wpr-846239
ABSTRACT
Objective:
To investigate the mechanism of berberine regulating glycogen metabolism and its effect on glycogen structure.Methods:
The db/db mice were used as diabetic mice to investigate the effect of berberine on blood glucose levels in db/db mice. The liver glycogen was extracted for SEC and TEM analysis to investigate the effect of berberine on liver glycogen and the mechanism of its effect.Results:
Berberine significantly decreased the fasting blood glucose level and the insulin level in serum of db/db mice, and berberine repaired the damaged glycogen structure. Meanwhile, berberine decreased the expression of GP, GDBE, cAMP in liver tissue and the glucagon level in serum of db/db mice.Conclusion:
Berberine regulated the cAMP/GP signaling pathway, improved hepatic glycogen structure in db/db mice, and repaired damaged glycogen structure, which may be one of the mechanisms for regulating hepatic glucose metabolism and improving symptoms of diabetes.
Texto completo:
DisponíveL
Índice:
WPRIM (Pacífico Ocidental)
Idioma:
Chinês
Revista:
Chinese Traditional and Herbal Drugs
Ano de publicação:
2020
Tipo de documento:
Artigo
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